| Gene Information | |
|---|---|
| Gene Name | IL33 |
| Organism | Homo sapiens (Human) |
| Gene Length | 270 |
| Protein Names | Interleukin-33 (IL-33) (Interleukin-1 family member 11) (IL-1F11) (Nuclear factor from high endothelial venules) (NF-HEV) [Cleaved into: Interleukin-33 (95-270); Interleukin-33 (99-270); Interleukin-33 (109-270)] |
| Target Name | interleukin-33 |
| Target Type | Clinical trial target |
| Gene Age | 168 ( ENSG00000137033 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | O95760 |
| Gene Card | IL33 |
| Uniprot ID | O95760 |
| Pfam | PF15095 |
| In ASD | no |
| Allosteric Prediction | yes (0.242374918) |
| Ortholog in Animals | Alpaca_ IL33 ( ortholog_one2one ) Dog_ IL33 ( ortholog_one2one ) GuineaPig_ IL33 ( ortholog_one2one ) Macaque_ IL33 ( ortholog_one2one ) Mouse_ Il33 ( ortholog_one2one ) Pig_ IL33 ( ortholog_one2one ) Rat_ Il33 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta. {ECO:0000269|PubMed:12819012}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2KLL (NMR - ) 4KC3 (X-ray 3.27A ) |
| DBSNP | rs16924241 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12819012, ECO:0000269|PubMed:17185418, ECO:0000269|PubMed:18787100, ECO:0000269|PubMed:18836528, ECO:0000269|PubMed:21734074}. Chromosome {ECO:0000269|PubMed:17185418}. Cytoplasm {ECO:0000269|PubMed:32272059}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:22215666}. Secreted {ECO:0000269|PubMed:19465481}. Note=Associates with heterochromatin and mitotic chromosomes (PubMed:17185418). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). {ECO:0000269|PubMed:32272059}. |
| Mouse PG classification | NA |
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