Gene Information
Gene NameIL2RG
OrganismHomo sapiens (Human)
Gene Length369
Protein NamesCytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)
Target Namecytokine receptor common subunit gamma
Target TypeNA
Gene Age645 ( ENSG00000147168 )
Evolutionary StageVertebrata
AlphaFoldDBP31785
Gene CardIL2RG
Uniprot IDP31785
PfamPF09240
In ASDno
Allosteric Predictionyes (0.389415288)
Ortholog in AnimalsAlpaca_ IL2RG ( ortholog_one2one )
Dog_ IL2RG ( ortholog_one2one )
GuineaPig_ IL2RG ( ortholog_one2one )
Macaque_ IL2RG ( ortholog_one2one )
Mouse_ Il2rg ( ortholog_one2one )
Pig_ IL2RG ( ortholog_one2one )
Rat_ Il2rg ( ortholog_one2one )
OhnologsNA
ParalogsCRLF1, IL13RA2, IL11RA, IL13RA1, CNTFR, CRLF2, IL31RA, IL3RA, IL6ST, IL12RB1, CSF3R, IL12RB2, GHR, CSF2RA, IL6R, IL27RA, IL23R, LIFR, OSMR, IL5RA, EBI3, PRLR, LEPR
Tissuewhole.blood
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.003133(Rat);0.1(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2B5I  (X-ray  2.30A  )  2ERJ  (X-ray  3.00A  )  3BPL  (X-ray  2.93A  )  3QAZ  (X-ray  3.80A  )  3QB7  (X-ray  3.24A  )  4GS7  (X-ray  2.35A  )  5M5E  (X-ray  2.30A  )  6OEL  (X-ray  3.10A  )  7S2R  (X-ray  2.49A  ) 
DBSNP rs7885041  rs1057520644  rs193922347  rs17875899  rs111033620  rs111033622  rs111033621  rs1057521062  rs111033618  rs869320658  rs869320659  rs869320660  rs1569479909  rs111033617  rs137852510 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:15123770};
Single-pass type I membrane protein {ECO:0000255}. Cell surface {ECO:0000269|PubMed:15123770}.
Mouse PG classificationNA
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