| Gene Information | |
|---|---|
| Gene Name | IL2RB |
| Organism | Homo sapiens (Human) |
| Gene Length | 551 |
| Protein Names | Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122) |
| Target Name | interleukin 2 receptor beta |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000100385 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P14784 |
| Gene Card | IL2RB |
| Uniprot ID | P14784 |
| Pfam | PF18707 |
| In ASD | no |
| Allosteric Prediction | no (-0.118262671) |
| Ortholog in Animals | Alpaca_ IL2RB ( ortholog_one2one ) Dog_ IL2RB ( ortholog_one2one ) GuineaPig_ IL2RB ( ortholog_one2one ) Macaque_ IL2RB ( ortholog_one2one ) Mouse_ Il2rb ( ortholog_one2one ) Pig_ IL2RB ( ortholog_one2one ) Rat_ Il2rb ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MPL, IL4R, IL7R, IL9R, IL21R, CSF2RB, EPOR |
| Tissue | placenta, spleen, whole.blood |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2B5I (X-ray 2.30A ) 2ERJ (X-ray 3.00A ) 3QAZ (X-ray 3.80A ) 4GS7 (X-ray 2.35A ) 5M5E (X-ray 2.30A ) 6E8K (X-ray 1.71A ) 7S2S (X-ray 1.93A ) |
| DBSNP | rs57770674 rs934523851 rs2228143 rs228942 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:31040184, ECO:0000269|PubMed:31040185}; Single-pass type I membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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