| Gene Information | |
|---|---|
| Gene Name | IL23R |
| Organism | Homo sapiens (Human) |
| Gene Length | 629 |
| Protein Names | Interleukin-23 receptor (IL-23 receptor) (IL-23R) |
| Target Name | interleukin 23 receptor |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000162594 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q5VWK5 |
| Gene Card | IL23R |
| Uniprot ID | Q5VWK5 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.543040237) |
| Ortholog in Animals | Alpaca_ IL23R ( ortholog_one2one ) Dog_ IL23R ( ortholog_one2one ) Macaque_ IL23R ( ortholog_one2one ) Mouse_ Il23r ( ortholog_one2one ) Pig_ IL23R ( ortholog_one2one ) Rat_ Il23r ( ortholog_one2one ) Rabbit_ IL23R ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CRLF1, IL13RA2, IL11RA, IL13RA1, CNTFR, IL2RG, CRLF2, IL31RA, IL3RA, IL6ST, IL12RB1, CSF3R, IL12RB2, GHR, CSF2RA, IL6R, IL27RA, LIFR, OSMR, IL5RA, EBI3, PRLR, LEPR |
| Tissue | NA |
| Tissue Specificity | Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. {ECO:0000269|PubMed:12023369, ECO:0000269|PubMed:16372191}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.005990(Rat);0.200000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5MZV (X-ray 2.80A ) 6WDQ (X-ray 3.40A ) |
| DBSNP | rs1884444 rs11465797 rs7530511 rs11209026 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12023369}; Single-pass type I membrane protein {ECO:0000269|PubMed:12023369}. |
| Mouse PG classification | NA |
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