| Gene Information | |
|---|---|
| Gene Name | IL22R |
| Organism | Homo sapiens (Human) |
| Gene Length | 574 |
| Protein Names | Interleukin-22 receptor subunit alpha-1 (IL-22 receptor subunit alpha-1) (IL-22R-alpha-1) (IL-22RA1) (Cytokine receptor class-II member 9) (Cytokine receptor family 2 member 9) (CRF2-9) (ZcytoR11) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8N6P7 |
| Gene Card | IL22RA1 |
| Uniprot ID | Q8N6P7 |
| Pfam | PF01108 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions; Strongly expressed on central nervous system vessels within infiltrated multiple sclerosis lesions. Overexpressed in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. {ECO:0000269|PubMed:12407026, ECO:0000269|PubMed:15308104, ECO:0000269|PubMed:17828272, ECO:0000269|PubMed:17900301, ECO:0000269|PubMed:18061474}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3DGC (X-ray 2.50A ) 3DLQ (X-ray 1.90A ) 6DF3 (X-ray 2.15A ) |
| DBSNP | rs34900099 rs16829204 rs34379702 rs34782294 rs35401673 rs3795299 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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