| Gene Information | |
|---|---|
| Gene Name | KCNJ1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 391 |
| Protein Names | ATP-sensitive inward rectifier potassium channel 1 (ATP-regulated potassium channel ROM-K) (Inward rectifier K(+) channel Kir1.1) (Potassium channel, inwardly rectifying subfamily J member 1) |
| Target Name | atp-sensitive inward rectifier potassium channel 1 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000151704 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P48048 |
| Gene Card | KCNJ1 |
| Uniprot ID | P48048 |
| Pfam | PF01007; PF17655 |
| In ASD | no |
| Allosteric Prediction | yes (1.25532575) |
| Ortholog in Animals | Alpaca_ KCNJ1 ( ortholog_one2one ) Dog_ KCNJ1 ( ortholog_one2one ) GuineaPig_ KCNJ1 ( ortholog_one2one ) Macaque_ KCNJ1 ( ortholog_one2one ) Mouse_ Kcnj1 ( ortholog_one2one ) Pig_ KCNJ1 ( ortholog_one2one ) Rat_ Kcnj1 ( ortholog_one2one ) Rabbit_ KCNJ1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KCNJ15, KCNJ10, KCNJ13, KCNJ11, KCNJ8, KCNJ14, KCNJ18, KCNJ4, KCNJ16, KCNJ12, KCNJ2, KCNJ9, KCNJ3, KCNJ5, KCNJ6 |
| Tissue | kidney, cortex.of.kidney |
| Tissue Specificity | In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver. {ECO:0000269|PubMed:7635463}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs34191956 rs1213764655 rs104894250 rs373745258 rs766131330 rs104894251 rs104894254 rs104894253 rs104894246 rs104894245 rs753949204 rs59172778 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12684516}; Multi-pass membrane protein {ECO:0000269|PubMed:12684516}. Note=Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane. {ECO:0000269|PubMed:12684516}. |
| Mouse PG classification | NA |
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