| Gene Information | |
|---|---|
| Gene Name | RAP1GAP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 730 |
| Protein Names | Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000132359 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q684P5 |
| Gene Card | RAP1GAP2 |
| Uniprot ID | Q684P5 |
| Pfam | PF02145 |
| In ASD | no |
| Allosteric Prediction | no (-0.452206275) |
| Ortholog in Animals | Alpaca_ RAP1GAP2 ( ortholog_one2one ) Dog_ RAP1GAP2 ( ortholog_one2one ) GuineaPig_ RAP1GAP2 ( ortholog_one2one ) Macaque_ RAP1GAP2 ( ortholog_one2one ) Mouse_ Rap1gap2 ( ortholog_one2one ) Pig_ RAP1GAP2 ( ortholog_one2one ) Rat_ Rap1gap2 ( ortholog_one2one ) Rabbit_ RAP1GAP2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SIPA1L2, SIPA1L1, SIPA1L3, SIPA1, RAP1GAP, GARNL3 |
| Tissue | NA |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in platelets with isoform 2 being the predominant form. Expressed in lymphocytes, heart, testis and pancreas. {ECO:0000269|PubMed:15632203}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17762452 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15632203}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15632203}. |
| Mouse PG classification | NA |
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