| Gene Information | |
|---|---|
| Gene Name | IL1RL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 575 |
| Protein Names | Interleukin-1 receptor-like 2 (EC 3.2.2.6) (IL-36 receptor) (IL-36R) (Interleukin-1 receptor-related protein 2) (IL-1Rrp2) (IL1R-rp2) |
| Target Name | il-1 receptor-like 2 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000115598 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9HB29 |
| Gene Card | IL1RL2 |
| Uniprot ID | Q9HB29 |
| Pfam | PF13895; PF01582 |
| In ASD | no |
| Allosteric Prediction | no (-1.099708208) |
| Ortholog in Animals | Alpaca_ IL1RL2 ( ortholog_one2one ) Dog_ IL1RL2 ( ortholog_one2one ) GuineaPig_ IL1RL2 ( ortholog_one2one ) Macaque_ IL1RL2 ( ortholog_one2one ) Mouse_ Il1rl2 ( ortholog_one2one ) Pig_ IL1RL2 ( ortholog_one2one ) Rat_ Il1rl2 ( ortholog_one2one ) Rabbit_ IL1RL2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IL1R1, IL1RL1, LAG3, IL1R2, IL18R1, SIGIRR, IL18RAP, IL1RAPL1, IL1RAPL2, IL1RAP |
| Tissue | NA |
| Tissue Specificity | Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level. {ECO:0000269|PubMed:16646978, ECO:0000269|PubMed:24829417}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6U6U (X-ray 2.31A ) |
| DBSNP | rs13405631 rs33946385 rs2302612 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein {ECO:0000269|PubMed:24829417}. |
| Mouse PG classification | NA |
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