| Gene Information | |
|---|---|
| Gene Name | IL1RAPL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 686 |
| Protein Names | X-linked interleukin-1 receptor accessory protein-like 2 (IL-1 receptor accessory protein-like 2) (IL-1-RAPL-2) (IL-1RAPL-2) (IL1RAPL-2) (EC 3.2.2.6) (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R-9) (IL-1R9) (Three immunoglobulin domain-containing IL-1 receptor-related 1) (TIGIRR-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000189108 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NP60 |
| Gene Card | IL1RAPL2 |
| Uniprot ID | Q9NP60 |
| Pfam | PF00047; PF13895; PF01582 |
| In ASD | no |
| Allosteric Prediction | no (-1.474635063) |
| Ortholog in Animals | Alpaca_ IL1RAPL2 ( ortholog_one2one ) Dog_ IL1RAPL2 ( ortholog_one2one ) GuineaPig_ IL1RAPL2 ( ortholog_one2one ) Macaque_ IL1RAPL2 ( ortholog_one2one ) Mouse_ Il1rapl2 ( ortholog_one2one ) Pig_ IL1RAPL2 ( ortholog_one2one ) Rat_ Il1rapl2 ( ortholog_one2one ) Rabbit_ IL1RAPL2 ( ortholog_one2one ) |
| Ohnologs | IL1RL1, IL18R1, IL18RAP, IL1RAPL1, IL1RAP |
| Paralogs | IL1R1, LAG3, IL18R1, IL1R2, IL1RL1, IL1RL2, SIGIRR, IL18RAP, IL1RAP, IL1RAPL1 |
| Tissue | NA |
| Tissue Specificity | Detected at low levels in fetal and adult brain, in particular in the frontal lobe, temporal lobe and cerebellum. Detected at very low levels in skin, liver, fetal ovary and in placenta. {ECO:0000269|PubMed:10882729, ECO:0000269|PubMed:11031108, ECO:0000269|PubMed:11587848}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7FD3 (X-ray 2.99A ) 7SZL (X-ray 2.30A ) |
| DBSNP | NA |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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