| Gene Information | |
|---|---|
| Gene Name | IL1R1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 569 |
| Protein Names | Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)] |
| Target Name | interleukin-1 receptor type 1 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000115594 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P14778 |
| Gene Card | IL1R1 |
| Uniprot ID | P14778 |
| Pfam | PF13895; PF18452; PF01582 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000054274) |
| Ortholog in Animals | Alpaca_ IL1R1 ( ortholog_one2one ) Dog_ IL1R1 ( ortholog_one2one ) GuineaPig_ IL1R1 ( ortholog_one2one ) Macaque_ IL1R1 ( ortholog_one2one ) Mouse_ Il1r1 ( ortholog_one2one ) Pig_ IL1R1 ( ortholog_one2one ) Rat_ Il1r1 ( ortholog_one2one ) Rabbit_ IL1R1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IL1RL2, IL1RL1, LAG3, IL1R2, IL18R1, SIGIRR, IL18RAP, IL1RAPL1, IL1RAPL2, IL1RAP |
| Tissue | NA |
| Tissue Specificity | Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells. {ECO:0000269|PubMed:10653850}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002528(Rat);0.030769(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1G0Y (X-ray 3.00A ) 1IRA (X-ray 2.70A ) 1ITB (X-ray 2.50A ) 4DEP (X-ray 3.10A ) 4GAF (X-ray 2.15A ) |
| DBSNP | rs2228139 rs28362304 |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:8142597}; Single-pass type I membrane protein {ECO:0000269|PubMed:8142597}. Cell membrane {ECO:0000305|PubMed:8142597}. Secreted {ECO:0000269|PubMed:8142597}. |
| Mouse PG classification | NA |
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