Gene Information
Gene NameIL1R1
OrganismHomo sapiens (Human)
Gene Length569
Protein NamesInterleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
Target Nameinterleukin 1 receptor type 1
Target TypeSuccessful target
Gene Age645 ( ENSG00000115594 )
Evolutionary StageEumetazoa
AlphaFoldDBP14778
Gene CardIL1R1
Uniprot IDP14778
PfamPF13895; PF18452; PF01582
In ASDyes
Allosteric Predictionyes (1.000054274)
Ortholog in AnimalsAlpaca_ IL1R1 ( ortholog_one2one )
Dog_ IL1R1 ( ortholog_one2one )
GuineaPig_ IL1R1 ( ortholog_one2one )
Macaque_ IL1R1 ( ortholog_one2one )
Mouse_ Il1r1 ( ortholog_one2one )
Pig_ IL1R1 ( ortholog_one2one )
Rat_ Il1r1 ( ortholog_one2one )
Rabbit_ IL1R1 ( ortholog_one2one )
OhnologsNA
ParalogsIL1RL2, IL1RL1, LAG3, IL1R2, IL18R1, SIGIRR, IL18RAP, IL1RAPL1, IL1RAPL2, IL1RAP
TissueNA
Tissue SpecificityExpressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells. {ECO:0000269|PubMed:10653850}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.002528(Rat);0.030769(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1G0Y  (X-ray  3.00A  )  1IRA  (X-ray  2.70A  )  1ITB  (X-ray  2.50A  )  4DEP  (X-ray  3.10A  )  4GAF  (X-ray  2.15A  ) 
DBSNP rs2228139  rs28362304 
Subcellular location [CC]Membrane {ECO:0000269|PubMed:8142597};
Single-pass type I membrane protein {ECO:0000269|PubMed:8142597}. Cell membrane {ECO:0000305|PubMed:8142597}. Secreted {ECO:0000269|PubMed:8142597}.
Mouse PG classificationNA
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