| Gene Information | |
|---|---|
| Gene Name | HCN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 890 |
| Protein Names | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000164588 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O60741 |
| Gene Card | HCN1 |
| Uniprot ID | O60741 |
| Pfam | PF00027; PF00520; PF08412 |
| In ASD | no |
| Allosteric Prediction | yes (0.380816332) |
| Ortholog in Animals | Alpaca_ HCN1 ( ortholog_one2one ) Dog_ HCN1 ( ortholog_one2one ) GuineaPig_ HCN1 ( ortholog_one2one ) Macaque_ HCN1 ( ortholog_one2one ) Mouse_ Hcn1 ( ortholog_one2one ) Pig_ HCN1 ( ortholog_one2one ) Rat_ Hcn1 ( ortholog_one2one ) Rabbit_ HCN1 ( ortholog_one2one ) |
| Ohnologs | HCN2, HCN4, HCN3 |
| Paralogs | KCNH7, KCNH1, HCN3, CNGA3, KCNH3, HCN4, HCN2, KCNH8, CNGB3, CNGB1, CNGA1, KCNH6, KCNH2, KCNH4, CNGA2, CNGA4, KCNH5 |
| Tissue | brain, cerebral.cortex |
| Tissue Specificity | Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas. {ECO:0000269|PubMed:9630217}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5U6O (EM 3.50A ) 5U6P (EM 3.51A ) 6UQF (EM 3.04A ) 6UQG (EM 3.54A ) |
| DBSNP | rs56164833 rs544994462 rs587777492 rs1057519548 rs1561230606 rs1561230486 rs1554037378 rs763339068 rs587777493 rs587777495 rs587777494 rs1057521989 rs1318391259 rs1057519547 rs1561139569 rs587777491 rs1561120793 rs1561081319 rs1486444621 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15351778, ECO:0000269|PubMed:28086084, ECO:0000269|PubMed:30351409}; Multi-pass membrane protein {ECO:0000269|PubMed:15351778, ECO:0000269|PubMed:28086084, ECO:0000269|PubMed:30351409}. |
| Mouse PG classification | LPG |
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