| Gene Information | |
|---|---|
| Gene Name | IL1F7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 218 |
| Protein Names | Interleukin-37 (IL-37) (FIL1 zeta) (IL-1X) (Interleukin-1 family member 7) (IL-1F7) (Interleukin-1 homolog 4) (IL-1H) (IL-1H4) (Interleukin-1 zeta) (IL-1 zeta) (Interleukin-1-related protein) (IL-1RP1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9NZH6 |
| Gene Card | IL37 |
| Uniprot ID | Q9NZH6 |
| Pfam | PF00340 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart. {ECO:0000269|PubMed:11145836, ECO:0000269|PubMed:20935647}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5HN1 (X-ray 2.25A ) 6NCU (X-ray 3.50A ) |
| DBSNP | rs3811046 rs3811047 rs2708943 rs2723183 rs2723187 rs28947200 rs2708947 rs2723192 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:20935647}. Nucleus {ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:20935647, ECO:0000269|PubMed:33674380}. Secreted {ECO:0000269|PubMed:11145836, ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:33674380}. Note=Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions (PubMed:20935647, PubMed:33674380). Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation (PubMed:18390730). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059, PubMed:33674380). {ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:20935647, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:33674380}. |
| Mouse PG classification | NA |
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