Gene Information
Gene NameYWHAB
OrganismHomo sapiens (Human)
Gene Length246
Protein Names14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Target Name14-3-3 protein beta/alpha
Target TypeNA
Gene Age544 ( ENSG00000166913 )
Evolutionary StageEukaryota
AlphaFoldDBP31946
Gene CardYWHAB
Uniprot IDP31946
PfamPF00244
In ASDno
Allosteric Predictionyes (1.022115962)
Ortholog in AnimalsAlpaca_ YWHAB ( ortholog_one2one )
GuineaPig_ YWHAB ( ortholog_one2one )
Macaque_ YWHAB ( ortholog_one2one )
Mouse_ Ywhab ( ortholog_one2one )
Pig_ YWHAB ( ortholog_one2one )
Rat_ Ywhab ( ortholog_one2one )
Rabbit_ YWHAB ( ortholog_one2one )
OhnologsYWHAH, YWHAQ, YWHAZ, SFN
ParalogsYWHAZ, YWHAE, YWHAH, YWHAG, YWHAQ, SFN
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2BQ0  (X-ray  2.50A  2C23  (X-ray  2.65A  4DNK  (X-ray  2.20A  5N10  (X-ray  1.60A  6A5Q  (X-ray  2.00A  6BYK  (X-ray  3.00A  6GN0  (X-ray  3.24A  6GN8  (X-ray  2.34A  6GNJ  (X-ray  3.24A  6GNK  (X-ray  2.55A  6GNN  (X-ray  3.79A  6HEP  (X-ray  1.86A 
DBSNP NA 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.;
Vacuole membrane {ECO:0000269|PubMed:11260479}. Note=(Microbial infection) Upon infection with Chlamydia trachomatis, this protein is associated with the pathogen-containing vacuole membrane where it colocalizes with IncG. {ECO:0000269|PubMed:11260479}.
Mouse PG classificationNA
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