| Gene Information | |
|---|---|
| Gene Name | IL1F10 |
| Organism | Homo sapiens (Human) |
| Gene Length | 152 |
| Protein Names | Interleukin-1 family member 10 (IL-1F10) (Family of interleukin 1-theta) (FIL1 theta) (Interleukin-1 HY2) (IL-1HY2) (Interleukin-1 theta) (IL-1 theta) (Interleukin-38) (IL-38) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000136697 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8WWZ1 |
| Gene Card | IL1F10 |
| Uniprot ID | Q8WWZ1 |
| Pfam | PF00340 |
| In ASD | no |
| Allosteric Prediction | no (-0.967297386) |
| Ortholog in Animals | Alpaca_ IL1F10 ( ortholog_one2one ) GuineaPig_ IL1F10 ( ortholog_one2one ) Macaque_ IL1F10 ( ortholog_one2one ) Mouse_ Il1f10 ( ortholog_one2one ) Rat_ Il1f10 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IL1RN, IL36RN, IL36G, IL37, IL36A, IL36B, IL1B |
| Tissue | NA |
| Tissue Specificity | Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5BOW (X-ray 1.31A ) |
| DBSNP | rs6761276 rs6743376 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:32272059}. Secreted {ECO:0000269|PubMed:32272059}. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000269|PubMed:32272059}. |
| Mouse PG classification | NA |
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