| Gene Information | |
|---|---|
| Gene Name | IL1BC |
| Organism | Homo sapiens (Human) |
| Gene Length | 404 |
| Protein Names | Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P29466 |
| Gene Card | CASP1 |
| Uniprot ID | P29466 |
| Pfam | PF00619 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. {ECO:0000269|PubMed:15498465}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002101(Rat);0.02(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1BMQ (X-ray 2.50A ) 1IBC (X-ray 2.73A ) 1ICE (X-ray 2.60A ) 1RWK (X-ray 2.30A ) 1RWM (X-ray 2.70A ) 1RWN (X-ray 2.00A ) 1RWO (X-ray 2.10A ) 1RWP (X-ray 2.20A ) 1RWV (X-ray 2.10A ) 1RWW (X-ray 2.80A ) 1RWX (X-ray 1.85A ) 1SC1 (X-ray 2.60A ) 1SC3 (X-ray 1.80A ) 1SC4 (X-ray 2.10A ) 2FQQ (X-ray 3.30A ) 2H48 (X-ray 2.20A ) 2H4W (X-ray 2.00A ) 2H4Y (X-ray 1.90A ) 2H51 (X-ray 2.10A ) 2H54 (X-ray 1.80A ) 2HBQ (X-ray 1.80A ) 2HBR (X-ray 2.20A ) 2HBY (X-ray 2.10A ) 2HBZ (X-ray 1.90A ) 3D6F (X-ray 1.90A ) 3D6H (X-ray 2.00A ) 3D6M (X-ray 1.80A ) 3E4C (X-ray 2.05A ) 3NS7 (X-ray 2.60A ) 5FNA (EM 4.80A ) 5MMV (X-ray 2.15A ) 5MTK (X-ray 2.53A ) 6BZ9 (X-ray 1.80A ) 6F6R (X-ray 1.80A ) 6KN0 (X-ray 2.79A ) 6PZP (X-ray 1.94A ) 6VIE (X-ray 3.40A ) 7KEU (EM 3.90A ) |
| DBSNP | rs1042743 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:20197547}. Cell membrane {ECO:0000269|PubMed:20197547}. |
| Mouse PG classification | NA |
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