| Gene Information | |
|---|---|
| Gene Name | IL1B |
| Organism | Homo sapiens (Human) |
| Gene Length | 269 |
| Protein Names | Interleukin-1 beta (IL-1 beta) (Catabolin) |
| Target Name | interleukin-1 beta |
| Target Type | Successful target |
| Gene Age | 454 ( ENSG00000125538 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P01584 |
| Gene Card | IL1B |
| Uniprot ID | P01584 |
| Pfam | PF00340; PF02394 |
| In ASD | yes |
| Allosteric Prediction | yes (1.176202547) |
| Ortholog in Animals | Alpaca_ IL1B ( ortholog_one2one ) Dog_ IL1B ( ortholog_one2one ) GuineaPig_ IL1B ( ortholog_one2one ) Macaque_ IL1B ( ortholog_one2one ) Mouse_ Il1b ( ortholog_one2one ) Pig_ IL1B2 ( ortholog_one2many ) Rat_ Il1b ( ortholog_one2one ) Rabbit_ IL1B ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IL36G, IL37, IL1F10, IL1RN, IL36RN, IL36A, IL36B |
| Tissue | NA |
| Tissue Specificity | Expressed in activated monocytes/macrophages (at protein level). {ECO:0000269|PubMed:15192144}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1HIB (X-ray 2.40A ) 1I1B (X-ray 2.00A ) 1IOB (X-ray 2.00A ) 1ITB (X-ray 2.50A ) 1L2H (X-ray 1.54A ) 1S0L (X-ray 2.34A ) 1T4Q (X-ray 2.10A ) 1TOO (X-ray 2.10A ) 1TP0 (X-ray 2.20A ) 1TWE (X-ray 2.10A ) 1TWM (X-ray 2.26A ) 21BI (X-ray 2.00A ) 2I1B (X-ray 2.00A ) 2KH2 (NMR - ) 2NVH (X-ray 1.53A ) 31BI (X-ray 2.00A ) 3LTQ (X-ray 2.10A ) 3O4O (X-ray 3.30A ) 3POK (X-ray 1.70A ) 41BI (X-ray 2.90A ) 4DEP (X-ray 3.10A ) 4G6J (X-ray 2.03A ) 4G6M (X-ray 1.81A ) 4GAF (X-ray 2.15A ) 4GAI (X-ray 1.49A ) 4I1B (X-ray 2.00A ) 5BVP (X-ray 2.20A ) 5I1B (X-ray 2.10A ) 5MVZ (X-ray 2.15A ) 5R7W (X-ray 1.27A ) 5R85 (X-ray 1.44A ) 5R86 (X-ray 1.50A ) 5R87 (X-ray 1.47A ) 5R88 (X-ray 1.48A ) 5R89 (X-ray 1.65A ) 5R8A (X-ray 1.47A ) 5R8B (X-ray 1.49A ) 5R8C (X-ray 1.54A ) 5R8D (X-ray 1.47A ) 5R8E (X-ray 1.35A ) 5R8F (X-ray 1.41A ) 5R8G (X-ray 1.43A ) 5R8H (X-ray 1.50A ) 5R8I (X-ray 1.47A ) 5R8J (X-ray 1.62A ) 5R8K (X-ray 1.47A ) 5R8L (X-ray 1.56A ) 5R8M (X-ray 1.39A ) 5R8N (X-ray 1.48A ) 5R8O (X-ray 1.42A ) 5R8P (X-ray 1.53A ) 5R8Q (X-ray 1.23A ) 6I1B (NMR - ) 6Y8I (X-ray 1.46A ) 6Y8M (X-ray 1.90A ) 7CHY (X-ray 2.65A ) 7CHZ (X-ray 2.50A ) 7I1B (NMR - ) 9ILB (X-ray 2.28A ) |
| DBSNP | rs144640380 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:15192144}. Secreted {ECO:0000269|PubMed:11728343, ECO:0000269|PubMed:15192144, ECO:0000269|PubMed:33883744}. Lysosome {ECO:0000269|PubMed:15192144}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:P10749}. Note=The precursor is cytosolic (PubMed:15192144). In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted (PubMed:24201029, PubMed:33377178, PubMed:33883744). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:15192144, ECO:0000269|PubMed:24201029, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:33377178, ECO:0000269|PubMed:33883744}. |
| Mouse PG classification | LPG |
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