| Gene Information | |
|---|---|
| Gene Name | IL1A |
| Organism | Homo sapiens (Human) |
| Gene Length | 271 |
| Protein Names | Interleukin-1 alpha (IL-1 alpha) (Hematopoietin-1) |
| Target Name | interleukin-1 alpha |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000115008 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P01583 |
| Gene Card | IL1A |
| Uniprot ID | P01583 |
| Pfam | PF00340; PF02394 |
| In ASD | no |
| Allosteric Prediction | yes (0.894554378) |
| Ortholog in Animals | Alpaca_ IL1A ( ortholog_one2one ) Dog_ IL1A ( ortholog_one2one ) GuineaPig_ IL1A ( ortholog_one2one ) Macaque_ IL1A ( ortholog_one2one ) Mouse_ Il1a ( ortholog_one2one ) Pig_ IL1A ( ortholog_one2one ) Rat_ Il1a ( ortholog_one2one ) Rabbit_ IL1A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | esophagus, testis, urinary.bladder, tongue, zone.of.skin, lung |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2ILA (X-ray 2.30A ) 2KKI (NMR - ) 2L5X (NMR - ) 5UC6 (X-ray 2.10A ) |
| DBSNP | rs3783531 rs17561 rs17562 rs3783581 rs1801715 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:26439902}. Cytoplasm {ECO:0000269|PubMed:32272059}. Secreted {ECO:0000269|PubMed:26439902}. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). Recruited to DNA damage sites and secreted after genotoxic stress. {ECO:0000269|PubMed:32272059}. |
| Mouse PG classification | NA |
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