| Gene Information | |
|---|---|
| Gene Name | MPIG6B |
| Organism | Homo sapiens (Human) |
| Gene Length | 241 |
| Protein Names | Megakaryocyte and platelet inhibitory receptor G6b (Protein G6b) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 70 ( ENSG00000204420 ) 3 ( ENSG00000206396 ) 3 ( ENSG00000224393 ) 3 ( ENSG00000228090 ) 3 ( ENSG00000230060 ) 3 ( ENSG00000231003 ) 3 ( ENSG00000237459 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | O95866 |
| Gene Card | MPIG6B |
| Uniprot ID | O95866 |
| Pfam | PF15096 |
| In ASD | no |
| Allosteric Prediction | no (-1.163777995) |
| Ortholog in Animals | Alpaca_ MPIG6B ( ortholog_one2one ) Dog_ MPIG6B ( ortholog_one2one ) GuineaPig_ MPIG6B ( ortholog_one2one ) Macaque_ MPIG6B ( ortholog_one2one ) Mouse_ Mpig6b ( ortholog_one2one ) Pig_ MPIG6B ( ortholog_one2one ) Rat_ Mpig6b ( ortholog_one2one ) Rabbit_ MPIG6B ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | spleen, substantia.nigra |
| Tissue Specificity | Expressed in platelets. Expressed in a restricted set of hematopoietic cell lines including the erythroleukemia cell line K-562 and the T-cell leukemia cell lines MOLT-4 and Jurkat. Not detected in the monocyte-like cell line U-937, the B-cell-like cell line Raji, the fibroblast cell lines TK and HeLa, or the natural killer cell lines NKL, NK 62 and YT. {ECO:0000269|PubMed:11544253, ECO:0000269|PubMed:17311996}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6R0X (X-ray 3.13A ) |
| DBSNP | rs11575845 |
| Subcellular location [CC] | [Isoform E]: Endoplasmic reticulum {ECO:0000269|PubMed:11544253}. Golgi apparatus {ECO:0000269|PubMed:11544253}.; [Isoform D]: Endoplasmic reticulum {ECO:0000269|PubMed:11544253}. Golgi apparatus {ECO:0000269|PubMed:11544253}.; [Isoform B]: Cell membrane {ECO:0000269|PubMed:11544253}; Single-pass type I membrane protein {ECO:0000305}.; [Isoform A]: Cell membrane {ECO:0000269|PubMed:11544253}; Single-pass type I membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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