| Gene Information | |
|---|---|
| Gene Name | IL18 |
| Organism | Homo sapiens (Human) |
| Gene Length | 193 |
| Protein Names | Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma) |
| Target Name | interleukin-18 |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000150782 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q14116 |
| Gene Card | IL18 |
| Uniprot ID | Q14116 |
| Pfam | PF00340 |
| In ASD | no |
| Allosteric Prediction | yes (0.30827887) |
| Ortholog in Animals | Alpaca_ IL18 ( ortholog_one2one ) Dog_ IL18 ( ortholog_one2one ) GuineaPig_ IL18 ( ortholog_one2one ) Macaque_ IL18 ( ortholog_one2one ) Mouse_ Il18 ( ortholog_one2one ) Pig_ IL18 ( ortholog_one2one ) Rat_ Il18 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.3(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1J0S (NMR - ) 2VXT (X-ray 1.49A ) 3F62 (X-ray 2.00A ) 3WO2 (X-ray 2.33A ) 3WO3 (X-ray 3.10A ) 3WO4 (X-ray 3.10A ) 4EEE (X-ray 2.71A ) 4EKX (X-ray 1.75A ) 4HJJ (X-ray 2.10A ) 4R6U (X-ray 2.80A ) 4XFS (X-ray 1.91A ) 4XFT (X-ray 2.00A ) 4XFU (X-ray 2.85A ) 7AL7 (X-ray 1.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:32272059}. Secreted {ECO:0000269|PubMed:23955712, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:33883744}. Note=The precursor is cytosolic (PubMed:33883744). In response to inflammasome-activating signals, cleaved and secreted (PubMed:33883744). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:33883744}. |
| Mouse PG classification | NA |
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