Gene Information
Gene NameIL10RA
OrganismHomo sapiens (Human)
Gene Length578
Protein NamesInterleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)
Target NameNA
Target TypeNA
Gene Age544 ( ENSG00000110324 )
Evolutionary StageVertebrata
AlphaFoldDBQ13651
Gene CardIL10RA
Uniprot IDQ13651
PfamPF01108
In ASDno
Allosteric Predictionno (-0.422392372)
Ortholog in AnimalsAlpaca_ IL10RA ( ortholog_one2one )
Dog_ IL10RA ( ortholog_one2one )
GuineaPig_ IL10RA ( ortholog_one2one )
Macaque_ IL10RA ( ortholog_one2one )
Mouse_ Il10ra ( ortholog_one2one )
Pig_ IL10RA ( ortholog_one2one )
Rat_ Il10ra ( ortholog_one2one )
Rabbit_ IL10RA ( ortholog_one2one )
OhnologsNA
ParalogsIFNAR1, IL22RA2, IFNGR2, IL22RA1, F3, IFNLR1, IL20RB, IL20RA, IFNAR2, IFNGR1, IL10RB
TissueNA
Tissue SpecificityPrimarily expressed in hematopoetic cells including B-cells, T-cells, NK cells, monocytes and macrophages. Not expressed in non-hematopoetic cells such as fibroblasts or endothelial cells.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.010990(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1J7V  (X-ray  2.90A  )  1LQS  (X-ray  2.70A  )  1Y6K  (X-ray  2.52A  )  1Y6M  (X-ray  2.80A  )  1Y6N  (X-ray  2.70A  )  5IXI  (X-ray  2.57A  )  6X93  (EM  3.50A  ) 
DBSNP rs4252250  rs1343534194  rs137853580  rs1591261607  rs368287711  rs4252303  rs199989396  rs137853579  rs3135932  rs4252273  rs2228055  rs149491038  rs2229113  rs35235073  rs2229114 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:22087322, ECO:0000269|PubMed:26962683};
Single-pass type I membrane protein. Cytoplasm {ECO:0000269|PubMed:26962683}.
Mouse PG classificationHPG
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