| Gene Information | |
|---|---|
| Gene Name | IL10 |
| Organism | Homo sapiens (Human) |
| Gene Length | 178 |
| Protein Names | Interleukin-10 (IL-10) (Cytokine synthesis inhibitory factor) (CSIF) |
| Target Name | interleukin-10 |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000136634 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P22301 |
| Gene Card | IL10 |
| Uniprot ID | P22301 |
| Pfam | PF00726 |
| In ASD | yes |
| Allosteric Prediction | yes (0.99984873) |
| Ortholog in Animals | Alpaca_ IL10 ( ortholog_one2one ) Dog_ IL10 ( ortholog_one2one ) GuineaPig_ IL10 ( ortholog_one2one ) Macaque_ IL10 ( ortholog_one2one ) Mouse_ Il10 ( ortholog_one2one ) Pig_ IL10 ( ortholog_one2one ) Rat_ Il10 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IL26, IL20, IL19, IL24 |
| Tissue | adipose.tissue |
| Tissue Specificity | Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types. {ECO:0000269|PubMed:1940799, ECO:0000269|PubMed:7512027}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002990(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1ILK (X-ray 1.80A ) 1INR (X-ray 2.00A ) 1J7V (X-ray 2.90A ) 1LK3 (X-ray 1.91A ) 1Y6K (X-ray 2.52A ) 2H24 (X-ray 2.00A ) 2ILK (X-ray 1.60A ) 6X93 (EM 3.50A ) |
| DBSNP | rs145922845 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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