| Gene Information | |
|---|---|
| Gene Name | IGSF8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 613 |
| Protein Names | Immunoglobulin superfamily member 8 (IgSF8) (CD81 partner 3) (Glu-Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes-associated transmembrane protein 4) (KCT-4) (LIR-D1) (Prostaglandin regulatory-like protein) (PGRL) (CD antigen CD316) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000162729 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q969P0 |
| Gene Card | IGSF8 |
| Uniprot ID | Q969P0 |
| Pfam | PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-0.971281818) |
| Ortholog in Animals | Alpaca_ IGSF8 ( ortholog_one2one ) Dog_ IGSF8 ( ortholog_one2one ) GuineaPig_ IGSF8 ( ortholog_one2one ) Macaque_ IGSF8 ( ortholog_one2one ) Mouse_ Igsf8 ( ortholog_one2one ) Pig_ IGSF8 ( ortholog_one2one ) Rat_ Igsf8 ( ortholog_one2one ) Rabbit_ IGSF8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | VSTM4, PTGFRN, VSTM2A, CD101, IGSF3 |
| Tissue | NA |
| Tissue Specificity | Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other tissues. Detected on a majority of B-cells, T-cells, and natural killer cells but not on monocytes, polynuclear cells and platelets. {ECO:0000269|PubMed:11504738, ECO:0000269|PubMed:12708969, ECO:0000269|PubMed:12750295}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Single-pass membrane protein. |
| Mouse PG classification | NA |
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