| Gene Information | |
|---|---|
| Gene Name | IKZF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 519 |
| Protein Names | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000185811 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q13422 |
| Gene Card | IKZF1 |
| Uniprot ID | Q13422 |
| Pfam | PF00096 |
| In ASD | no |
| Allosteric Prediction | no (-0.221242536) |
| Ortholog in Animals | Alpaca_ IKZF1 ( ortholog_one2one ) Dog_ IKZF1 ( ortholog_one2one ) GuineaPig_ IKZF1 ( ortholog_one2one ) Macaque_ IKZF1 ( ortholog_one2one ) Mouse_ Ikzf1 ( ortholog_one2one ) Pig_ IKZF1 ( ortholog_one2one ) Rat_ Ikzf1 ( ortholog_one2one ) Rabbit_ IKZF1 ( ortholog_one2one ) |
| Ohnologs | IKZF4, IKZF3, IKZF2 |
| Paralogs | ZNF613, ZNF649, ZNF821, ZNF567, ZNF639, ZNF382, IKZF4, IKZF3, ZNF350, ZNF564, IKZF2 |
| Tissue | spleen, whole.blood |
| Tissue Specificity | Abundantly expressed in thymus, spleen and peripheral blood Leukocytes and lymph nodes. Lower expression in bone marrow and small intestine. {ECO:0000269|PubMed:8543809, ECO:0000269|PubMed:8964602}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.027273(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6H0F (X-ray 3.25A ) 8D7Z (EM 3.10A ) 8D80 (EM 3.60A ) |
| DBSNP | rs770551610 rs770551610 rs869312884 rs869312885 rs869312883 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:21548011, ECO:0000269|PubMed:22106042, ECO:0000269|PubMed:23071339}. Note=In resting lymphocytes, distributed diffusely throughout the nucleus. Localizes to pericentromeric heterochromatin in proliferating cells. This localization requires DNA binding which is regulated by phosphorylation / dephosphorylation events. {ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:22106042}.; [Isoform Ik2]: Nucleus. Note=In resting lymphocytes, distributed diffusely throughout the nucleus. Localizes to pericentromeric heterochromatin in proliferating cells. This localization requires DNA binding which is regulated by phosphorylation / dephosphorylation events (By similarity). {ECO:0000250}.; [Isoform Ik6]: Cytoplasm {ECO:0000250}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |