Gene Information
Gene NameIKKB
OrganismHomo sapiens (Human)
Gene Length756
Protein NamesInhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBO14920
Gene CardIKBKB
Uniprot IDO14920
PfamPF18397; PF12179; PF00069
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityHighly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.402991(Rat);0.111316(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3BRT  (X-ray  2.25A  3BRV  (X-ray  2.20A  4E3C  (X-ray  3.98A  4KIK  (X-ray  2.83A 
DBSNP rs1563340753  rs56411242  rs2272736  rs17875749  rs34309584  rs56301637  rs17611716 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:20797629}. Nucleus {ECO:0000269|PubMed:20797629}. Membrane raft {ECO:0000269|PubMed:17287217}. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000269|PubMed:17287217}.
Mouse PG classificationNA
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