| Gene Information | |
|---|---|
| Gene Name | IKBR |
| Organism | Homo sapiens (Human) |
| Gene Length | 1378 |
| Protein Names | Tonsoku-like protein (Inhibitor of kappa B-related protein) (I-kappa-B-related protein) (IkappaBR) (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q96HA7 |
| Gene Card | TONSL |
| Uniprot ID | Q96HA7 |
| Pfam | PF12796; PF13516; PF13181 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in heart, skeletal muscle and tracheal epithelial cells. {ECO:0000269|PubMed:7738005}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001635(Rat);0.012121(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5JA4 (X-ray 2.42A ) |
| DBSNP | rs778155094 rs1335783881 rs563710728 rs2229314 rs2229315 rs775551492 rs370196996 rs777654833 rs778625348 rs755055463 rs7830832 rs755575416 rs1342198195 rs137933176 rs1586681982 rs4925856 rs1554878402 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:9242696}. Chromosome {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:26527279, ECO:0000269|PubMed:27338793, ECO:0000269|PubMed:29478807}. Cytoplasm {ECO:0000269|PubMed:7738005}. Note=Mainly nuclear (PubMed:21055983, PubMed:21055984). Localizes to DNA damage sites, accumulates at stressed replication forks (PubMed:21055983, PubMed:21055984, PubMed:26527279, PubMed:27338793). Recruited to stalled or collapsed replication forks following histone replacement by histone chaperones ASF1A and the CAF-1 complex: TONSL acts as histone reader that recognizes and binds newly synthesized histones (PubMed:29478807). {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:26527279, ECO:0000269|PubMed:27338793, ECO:0000269|PubMed:29478807}. |
| Mouse PG classification | NA |
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