Gene Information
Gene NameIKBKG
OrganismHomo sapiens (Human)
Gene Length419
Protein NamesNF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Target Namenf-kappa-b essential modulator
Target TypeNA
Gene Age454 ( ENSG00000269335 )
Evolutionary StageEumetazoa
AlphaFoldDBQ9Y6K9
Gene CardIKBKG
Uniprot IDQ9Y6K9
PfamPF16516; PF11577
In ASDno
Allosteric Predictionyes (0.829746915)
Ortholog in AnimalsAlpaca_ IKBKG ( ortholog_one2one )
Dog_ IKBKG ( ortholog_one2one )
GuineaPig_ IKBKG ( ortholog_one2one )
Macaque_ IKBKG ( ortholog_one2one )
Mouse_ Ikbkg ( ortholog_one2one )
Pig_ IKBKG ( ortholog_one2one )
Rat_ Ikbkg ( ortholog_one2one )
Rabbit_ IKBKG ( ortholog_one2one )
OhnologsNA
ParalogsOPTN
TissueNA
Tissue SpecificityHeart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2JVX  (NMR  -  )  2JVY  (NMR  -  )  3BRT  (X-ray  2.25A  )  3BRV  (X-ray  2.20A  )  3CL3  (X-ray  3.20A  )  3FX0  (X-ray  3.20A  )  4BWN  (X-ray  2.27A  )  5AAY  (NMR  -  )  5LDE  (X-ray  3.38A  )  6MI3  (X-ray  1.78A  )  6MI4  (X-ray  2.50A  )  6XX0  (X-ray  2.60A  )  6YEK  (X-ray  3.20A  )  7TV4  (X-ray  4.20A  ) 
DBSNP rs148695964  rs179363896  rs179363895  rs137853328  rs179363866  rs1057520292  rs179363868  rs1198984417  rs179363869  rs137853330  rs179363867  rs137853331  rs137853332  rs179363865  rs137853327  rs137853322  rs137853326  rs137853325  rs137853326 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:14651848}. Nucleus {ECO:0000269|PubMed:14651848}. Note=Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress. {ECO:0000269|PubMed:14651848}.
Mouse PG classificationNA
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