| Gene Information | |
|---|---|
| Gene Name | IKBKB |
| Organism | Homo sapiens (Human) |
| Gene Length | 756 |
| Protein Names | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) |
| Target Name | inhibitor of nuclear factor kappa-b kinase subunit beta |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000104365 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O14920 |
| Gene Card | IKBKB |
| Uniprot ID | O14920 |
| Pfam | PF18397; PF12179; PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (1.717885634) |
| Ortholog in Animals | Alpaca_ IKBKB ( ortholog_one2one ) Dog_ IKBKB ( ortholog_one2one ) GuineaPig_ IKBKB ( ortholog_one2one ) Macaque_ IKBKB ( ortholog_one2one ) Mouse_ Ikbkb ( ortholog_one2one ) Pig_ IKBKB ( ortholog_one2one ) Rat_ Ikbkb ( ortholog_one2one ) Rabbit_ IKBKB ( ortholog_one2one ) |
| Ohnologs | CHUK |
| Paralogs | CHUK, TBK1, IKBKE |
| Tissue | NA |
| Tissue Specificity | Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.402991(Rat);0.111316(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3BRT (X-ray 2.25A ) 3BRV (X-ray 2.20A ) 4E3C (X-ray 3.98A ) 4KIK (X-ray 2.83A ) |
| DBSNP | rs1563340753 rs56411242 rs2272736 rs17875749 rs34309584 rs56301637 rs17611716 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:20797629}. Nucleus {ECO:0000269|PubMed:20797629}. Membrane raft {ECO:0000269|PubMed:17287217}. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000269|PubMed:17287217}. |
| Mouse PG classification | NA |
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