Gene Information
Gene NameIKBKB
OrganismHomo sapiens (Human)
Gene Length756
Protein NamesInhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)
Target Nameinhibitor of nuclear factor kappa-b kinase beta
Target TypeClinical trial target
Gene Age810 ( ENSG00000104365 )
Evolutionary StageEumetazoa
AlphaFoldDBO14920
Gene CardIKBKB
Uniprot IDO14920
PfamPF18397; PF12179; PF00069
In ASDno
Allosteric Predictionyes (1.717885634)
Ortholog in AnimalsAlpaca_ IKBKB ( ortholog_one2one )
Dog_ IKBKB ( ortholog_one2one )
GuineaPig_ IKBKB ( ortholog_one2one )
Macaque_ IKBKB ( ortholog_one2one )
Mouse_ Ikbkb ( ortholog_one2one )
Pig_ IKBKB ( ortholog_one2one )
Rat_ Ikbkb ( ortholog_one2one )
Rabbit_ IKBKB ( ortholog_one2one )
OhnologsCHUK
ParalogsCHUK, TBK1, IKBKE
TissueNA
Tissue SpecificityHighly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.402991(Rat);0.111316(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3BRT  (X-ray  2.25A  3BRV  (X-ray  2.20A  4E3C  (X-ray  3.98A  4KIK  (X-ray  2.83A 
DBSNP rs1563340753  rs56411242  rs2272736  rs17875749  rs34309584  rs56301637  rs17611716 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:20797629}. Nucleus {ECO:0000269|PubMed:20797629}. Membrane raft {ECO:0000269|PubMed:17287217}. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000269|PubMed:17287217}.
Mouse PG classificationNA
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