| Gene Information | |
|---|---|
| Gene Name | IHH |
| Organism | Homo sapiens (Human) |
| Gene Length | 411 |
| Protein Names | Indian hedgehog protein (IHH) (EC 3.1.-.-) (HHG-2) [Cleaved into: Indian hedgehog protein N-product] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000163501 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q14623 |
| Gene Card | IHH |
| Uniprot ID | Q14623 |
| Pfam | PF01085; PF01079 |
| In ASD | no |
| Allosteric Prediction | no (-0.243011156) |
| Ortholog in Animals | Alpaca_ IHH ( ortholog_one2one ) Dog_ IHH ( ortholog_one2one ) GuineaPig_ IHH ( ortholog_one2one ) Macaque_ IHH ( ortholog_one2one ) Mouse_ Ihh ( ortholog_one2one ) Pig_ IHH ( ortholog_one2one ) Rat_ Ihh ( ortholog_one2one ) Rabbit_ IHH ( ortholog_one2one ) |
| Ohnologs | DHH, SHH |
| Paralogs | DHH, SHH |
| Tissue | transverse.colon |
| Tissue Specificity | Expressed in embryonic lung, and in adult kidney and liver. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004323(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3K7G (X-ray 1.50A ) 3K7H (X-ray 1.50A ) 3K7I (X-ray 1.44A ) 3K7J (X-ray 1.90A ) 3N1F (X-ray 1.60A ) 3N1M (X-ray 1.69A ) 3N1O (X-ray 2.55A ) 3N1P (X-ray 2.70A ) |
| DBSNP | rs121917856 rs121917852 rs121917854 rs121917855 rs121917853 rs121917857 |
| Subcellular location [CC] | [Indian hedgehog protein N-product]: Cell membrane {ECO:0000269|PubMed:21537345}; Lipid-anchor {ECO:0000250|UniProtKB:Q62226}. Note=The N-product remains associated with the cell surface. {ECO:0000250|UniProtKB:Q15465}.; [Indian hedgehog protein]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15465}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q15465}. Secreted {ECO:0000269|PubMed:24342078}. Note=Co-localizes with HHAT in the ER and Golgi membrane. {ECO:0000250|UniProtKB:Q15465}. |
| Mouse PG classification | HPG |
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