| Gene Information | |
|---|---|
| Gene Name | NRROS |
| Organism | Homo sapiens (Human) |
| Gene Length | 692 |
| Protein Names | Transforming growth factor beta activator LRRC33 (Leucine-rich repeat-containing protein 33) (Negative regulator of reactive oxygen species) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000174004 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q86YC3 |
| Gene Card | NRROS |
| Uniprot ID | Q86YC3 |
| Pfam | PF13516; PF13855 |
| In ASD | no |
| Allosteric Prediction | no (-1.278764956) |
| Ortholog in Animals | Alpaca_ NRROS ( ortholog_one2one ) Dog_ NRROS ( ortholog_one2one ) GuineaPig_ NRROS ( ortholog_one2one ) Macaque_ NRROS ( ortholog_one2one ) Mouse_ Nrros ( ortholog_one2one ) Pig_ NRROS ( ortholog_one2one ) Rat_ Nrros ( ortholog_one2one ) Rabbit_ NRROS ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CD180, RXFP1, TLR8, TLR5, TSKU, TLR7, TLR10, RXFP2, TLR6, LRRC3B, IGFALS, TLR3, TLR2, TLR4, LRRC17, LRRC32, LRRC53, VASN, TLR1, LRRC3C, LRRC3, LRIT2 |
| Tissue | NA |
| Tissue Specificity | Mainly expressed in cells of hematopoietic origin (PubMed:29909984). Highly expressed in bone marrow, thymus, liver, lung, intestine and spleen (PubMed:23545260). In the brain, highly expressed in microglia (PubMed:32100099). {ECO:0000269|PubMed:23545260, ECO:0000269|PubMed:32100099}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:23545260, ECO:0000269|PubMed:29909984}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:32197075}; Single-pass type I membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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