| Gene Information | |
|---|---|
| Gene Name | NTRK3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 839 |
| Protein Names | NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) |
| Target Name | nt-3 growth factor receptor |
| Target Type | Successful target |
| Gene Age | 544 ( ENSG00000140538 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q16288 |
| Gene Card | NTRK3 |
| Uniprot ID | Q16288 |
| Pfam | PF07679; PF00047; PF13855; PF16920; PF01462; PF07714 |
| In ASD | no |
| Allosteric Prediction | yes (0.762712411) |
| Ortholog in Animals | Alpaca_ NTRK3 ( ortholog_one2one ) Dog_ NTRK3 ( ortholog_one2one ) GuineaPig_ NTRK3 ( ortholog_one2one ) Macaque_ NTRK3 ( ortholog_one2one ) Mouse_ Ntrk3 ( ortholog_one2one ) Pig_ NTRK3 ( ortholog_one2one ) Rat_ Ntrk3 ( ortholog_one2one ) |
| Ohnologs | MUSK, NTRK2, NTRK1 |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET |
| Tissue | NA |
| Tissue Specificity | Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1WWC (X-ray 1.90A ) 3V5Q (X-ray 2.20A ) 4YMJ (X-ray 2.00A ) 6KZC (X-ray 2.00A ) 6KZD (X-ray 1.71A ) |
| DBSNP | rs200822610 rs200923715 rs147992979 rs368222977 rs547862658 rs56386352 rs1388363572 rs869112057 rs55890138 rs55770052 rs56393451 rs869209165 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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