| Gene Information | |
|---|---|
| Gene Name | BIRC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 618 |
| Protein Names | Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2) |
| Target Name | cellular inhibitor of apoptosis 1 |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000110330 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q13490 |
| Gene Card | BIRC2 |
| Uniprot ID | Q13490 |
| Pfam | PF00653; PF00619 |
| In ASD | no |
| Allosteric Prediction | yes (0.470054156) |
| Ortholog in Animals | Alpaca_ BIRC2 ( ortholog_one2one ) Dog_ BIRC2 ( ortholog_one2one ) GuineaPig_ BIRC2 ( ortholog_one2one ) Macaque_ BIRC2 ( ortholog_one2one ) Mouse_ Birc2 ( ortholog_one2one ) Pig_ BIRC2 ( ortholog_one2one ) Rat_ Birc2 ( ortholog_one2one ) Rabbit_ BIRC2 ( ortholog_one2one ) |
| Ohnologs | XIAP |
| Paralogs | NAIP, XIAP, BIRC7, NLRC4, BIRC6, BIRC5, BIRC3 |
| Tissue | NA |
| Tissue Specificity | Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001172(Rat);0.037931(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1QBH (NMR - ) 2L9M (NMR - ) 3D9T (X-ray 1.50A ) 3D9U (X-ray 2.30A ) 3M1D (X-ray 2.00A ) 3MUP (X-ray 2.60A ) 3OZ1 (X-ray 3.00A ) 3T6P (X-ray 1.90A ) 3UW4 (X-ray 1.79A ) 4EB9 (X-ray 2.60A ) 4HY4 (X-ray 1.25A ) 4HY5 (X-ray 1.75A ) 4KMN (X-ray 1.52A ) 4LGE (X-ray 1.55A ) 4LGU (X-ray 2.00A ) 4MTI (X-ray 2.15A ) 4MU7 (X-ray 1.79A ) 5M6N (X-ray 1.80A ) 6EXW (X-ray 2.20A ) 6HPR (X-ray 1.70A ) 6W74 (X-ray 2.11A ) 6W7O (X-ray 2.17A ) 6W8I (X-ray 3.80A ) 7QGJ (X-ray 1.30A ) |
| DBSNP | rs34749508 rs370745983 rs34510872 rs35494784 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Note=Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells. |
| Mouse PG classification | NA |
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