Gene Information
Gene NamePLEKHM1
OrganismHomo sapiens (Human)
Gene Length1056
Protein NamesPleckstrin homology domain-containing family M member 1 (PH domain-containing family M member 1) (162 kDa adapter protein) (AP162)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000225190 )
3 ( ENSG00000276358 )
3 ( ENSG00000277111 )
Evolutionary StageEukaryota
AlphaFoldDBQ9Y4G2
Gene CardPLEKHM1
Uniprot IDQ9Y4G2
PfamPF02759; PF13901
In ASDno
Allosteric Predictionno (-0.235569312)
Ortholog in AnimalsAlpaca_ PLEKHM1 ( ortholog_one2one )
GuineaPig_ PLEKHM1 ( ortholog_one2one )
Macaque_ PLEKHM1 ( ortholog_one2one )
Mouse_ Plekhm1 ( ortholog_one2one )
Pig_ PLEKHM1 ( ortholog_one2one )
Rat_ Plekhm1 ( ortholog_one2one )
Rabbit_ PLEKHM1 ( ortholog_one2one )
OhnologsNA
ParalogsDEF8, RUBCNL, RUBCN, PLEKHM3
TissueNA
Tissue SpecificityExpressed in placenta, liver, prostate, thymus, spleen, ovary, colon, colon carcinoma and peripheral blood lymphocytes (PBL). Weakly expressed in brain, lung, kidney, and testis. No expression in heart, skeletal muscle, pancreas and small intestine. Predominantly expressed in the breast carcinoma cell line MCF-7. {ECO:0000269|PubMed:12820725, ECO:0000269|PubMed:9205841}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5DPR  (X-ray  2.50A  )  5DPS  (X-ray  2.00A  )  5DPT  (X-ray  2.90A  )  5DPW  (X-ray  2.19A  ) 
DBSNP rs1859059  rs559224144 
Subcellular location [CC]Autolysosome membrane {ECO:0000269|PubMed:25498145}. Endosome membrane {ECO:0000269|PubMed:20943950}. Late endosome membrane {ECO:0000269|PubMed:28325809}. Lysosome membrane {ECO:0000269|PubMed:25498145, ECO:0000269|PubMed:25500191, ECO:0000269|PubMed:28325809}. Note=In case of infection colocalizes with Salmonella typhimurium sifA in proximity of Salmonella-containing vacuole (SCV) (PubMed:25500191). {ECO:0000269|PubMed:25498145, ECO:0000269|PubMed:25500191}.
Mouse PG classificationHPG
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