| Gene Information | |
|---|---|
| Gene Name | SH3D5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1292 |
| Protein Names | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9BX66 |
| Gene Card | SORBS1 |
| Uniprot ID | Q9BX66 |
| Pfam | PF00018; PF07653; PF14604; PF02208 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in skeletal muscle (at protein level). Widely expressed with highest levels in heart and skeletal muscle. {ECO:0000269|PubMed:11374898, ECO:0000269|PubMed:17462669}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2DL3 (NMR - ) 2ECZ (NMR - ) 2LJ0 (NMR - ) 2LJ1 (NMR - ) 2MOX (NMR - ) 2O2W (X-ray 2.27A ) 2O31 (X-ray 1.50A ) 2O9S (X-ray 0.83A ) 2O9V (X-ray 1.63A ) 4LN2 (X-ray 1.00A ) 4LNP (X-ray 1.41A ) |
| DBSNP | rs943542 rs757431022 rs7081076 rs2281939 rs35808802 |
| Subcellular location [CC] | Cell junction, adherens junction. Cell membrane. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus {ECO:0000250}. Nucleus matrix {ECO:0000250}. Note=Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation. {ECO:0000250}. |
| Mouse PG classification | NA |
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