| Gene Information | |
|---|---|
| Gene Name | TEKT3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 490 |
| Protein Names | Tektin-3 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000125409 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BXF9 |
| Gene Card | TEKT3 |
| Uniprot ID | Q9BXF9 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.678577523) |
| Ortholog in Animals | Alpaca_ TEKT3 ( ortholog_one2one ) Dog_ TEKT3 ( ortholog_one2one ) GuineaPig_ TEKT3 ( ortholog_one2one ) Macaque_ TEKT3 ( ortholog_one2one ) Mouse_ Tekt3 ( ortholog_one2one ) Pig_ TEKT3 ( ortholog_one2one ) Rat_ Tekt3 ( ortholog_one2one ) |
| Ohnologs | TEKT1, TEKT5, TEKT4 |
| Paralogs | TEKT5, TEKT2, TEKT1, TEKT4, MAFIP |
| Tissue | testis |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7226363 rs230898 rs6502446 rs35855709 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A6H782}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:A6H782, ECO:0000250|UniProtKB:Q4V8G8}. Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane {ECO:0000250|UniProtKB:A6H782, ECO:0000250|UniProtKB:Q4V8G8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q4V8G8}. Note=In the sperm flagellum, localizes to the periaxonemal region where it associates with the mitochondrial sheath and outer dense fibers (By similarity). Not detected in the central axonemal region of the flagellum (By similarity). Associates with the acrosome membrane in the equatorial segment of the sperm head (By similarity). Also detected just below the plasma membrane in the post-acrosomal region where it might localize to the postacrosomal dense lamina (By similarity). However, other studies report little or no expression in the postacrosomal region (By similarity). Translocates from the postacrosomal region to the equatorial segment after sperm activation (By similarity). Retained in the postacromal region, but not the equatorial segment, following the acrosome reaction (By similarity). Some studies report strong expression in the anterior cap region (By similarity). However, other studies report little or no expression in the acrosomal cap (By similarity). {ECO:0000250|UniProtKB:A6H782, ECO:0000250|UniProtKB:Q4V8G8}. |
| Mouse PG classification | NA |
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