| Gene Information | |
|---|---|
| Gene Name | IGHE |
| Organism | Homo sapiens (Human) |
| Gene Length | 428 |
| Protein Names | Immunoglobulin heavy constant epsilon (Ig epsilon chain C region) (Ig epsilon chain C region ND) |
| Target Name | immunoglobulin heavy constant epsilon |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000211891 ) |
| Evolutionary Stage | NA |
| AlphaFoldDB | P01854 |
| Gene Card | IGHE |
| Uniprot ID | P01854 |
| Pfam | PF07654 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | Macaque_ IGHE ( ortholog_one2one ) Mouse_ Ighe ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TRDC, IGHV4OR15-8, IGHV4-4, IGHV4-61, IGHV4-59, IGHV4-39, IGHV4-31, IGHV4-28, IGHV4-34, IGHV6-1, IGHV2-5, IGHV2OR16-5, IGHV2-26, IGHV2-70D, IGHV2-70, IGKC, IGHV5-51, IGHV5-10-1, IGHV1-69-2, IGHV1-24, IGHV1-3, IGHV1-58, IGHV1-45, IGHV1-18, IGHV1-69, IGHV1-69D, IGHV1-2, IGHV1OR15-1, IGHV1-46, IGHV1OR15-9, IGHV1OR21-1, IGHV3OR16-9, IGHV3OR16-8, IGHV3OR16-17, IGHV3-35, IGHV3-16, IGLL1, IGLC7, IGLC3, IGLC2, IGLC1, IGLL5, IGHV7-81, IGHV7-4-1, IGHG3, IGHG1, IGHG2, IGHG4, IGHM, IGHV3-13, IGHV3OR16-10, IGHV3-48, IGHV3-21, IGHV3-11, IGHV3-43, IGHV3-20, IGHV3-74, IGHV3OR16-13, IGHV3-73, IGHV3-72, IGHV3OR15-7, IGHV3-15, IGHV3-49, IGHV3-30, IGHV3-33, IGHV3-7, IGHV8-51-1, IGHV3-64D, IGHV3-64, IGHV3-23, IGHV3-66, IGHV3-53, IGHV3-38, IGHV3OR16-12, IGHA1, IGHA2, IGHD |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1F6A (X-ray 3.50A ) 1FP5 (X-ray 2.30A ) 1G84 (NMR - ) 1O0V (X-ray 2.60A ) 2WQR (X-ray 1.90A ) 2Y7Q (X-ray 3.40A ) 3H9Y (X-ray 2.23A ) 3H9Z (X-ray 2.45A ) 3HA0 (X-ray 2.80A ) 4EZM (X-ray 3.10A ) 4GKO (X-ray 3.30A ) 4GRG (X-ray 4.24A ) 4GT7 (X-ray 2.61A ) 4J4P (X-ray 2.91A ) 4KI1 (X-ray 3.20A ) 5ANM (X-ray 2.85A ) 5HYS (X-ray 2.50A ) 5LGJ (X-ray 2.60A ) 5LGK (X-ray 3.50A ) 5MOI (X-ray 2.20A ) 5MOJ (X-ray 2.26A ) 5MOK (X-ray 2.00A ) 5MOL (X-ray 1.75A ) 5NQW (X-ray 3.40A ) 6EYO (X-ray 3.70A ) 6UQR (X-ray 3.65A ) 7MXI (X-ray 2.80A ) 7SHT (EM 7.29A ) 7SHU (X-ray 2.75A ) 7SHY (X-ray 3.00A ) 7SHZ (X-ray 3.00A ) 7SI0 (X-ray 3.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. |
| Mouse PG classification | NA |
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