| Gene Information | |
|---|---|
| Gene Name | IGFR3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 254 |
| Protein Names | Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P08637 |
| Gene Card | FCGR3A |
| Uniprot ID | P08637 |
| Pfam | PF13895 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in natural killer cells (at protein level) (PubMed:2526846). Expressed in a subset of circulating monocytes (at protein level) (PubMed:27670158). {ECO:0000269|PubMed:2526846, ECO:0000269|PubMed:27670158}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3AY4 (X-ray 2.20A ) 3SGJ (X-ray 2.20A ) 3SGK (X-ray 2.40A ) 3WN5 (X-ray 2.78A ) 5BW7 (X-ray 3.00A ) 5D6D (X-ray 3.13A ) 5ML9 (X-ray 2.35A ) 5MN2 (X-ray 2.35A ) 5VU0 (X-ray 2.26A ) 5XJE (X-ray 2.40A ) 5XJF (X-ray 2.50A ) 5YC5 (X-ray 2.71A ) 7SEG (X-ray 2.16A ) |
| DBSNP | rs10127939 rs10127939 rs443082 rs396716 rs396991 rs1042206 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:1825220, ECO:0000269|PubMed:23006327, ECO:0000269|PubMed:24337742, ECO:0000269|PubMed:2532305, ECO:0000269|PubMed:28652325, ECO:0000269|PubMed:29967280}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:25816339, ECO:0000269|PubMed:29967280}. Note=Exists also as a soluble receptor. {ECO:0000269|PubMed:25816339, ECO:0000269|PubMed:29967280}. |
| Mouse PG classification | NA |
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