| Gene Information | |
|---|---|
| Gene Name | IGFBP3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 291 |
| Protein Names | Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3) |
| Target Name | insulin-like growth factor-binding protein 3 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000146674 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P17936 |
| Gene Card | IGFBP3 |
| Uniprot ID | P17936 |
| Pfam | PF00219; PF00086 |
| In ASD | no |
| Allosteric Prediction | yes (0.908003555) |
| Ortholog in Animals | Alpaca_ IGFBP3 ( ortholog_one2one ) Dog_ IGFBP3 ( ortholog_one2one ) GuineaPig_ IGFBP3 ( ortholog_one2one ) Macaque_ IGFBP3 ( ortholog_one2one ) Mouse_ Igfbp3 ( ortholog_one2one ) Pig_ IGFBP3 ( ortholog_one2one ) Rat_ Igfbp3 ( ortholog_one2one ) |
| Ohnologs | IGFBP4, IGFBP6, IGFBP2, IGFBP5 |
| Paralogs | IGFBP6, IGFBP2, IGFBP1, IGFBP5, IGFBP4 |
| Tissue | NA |
| Tissue Specificity | Expressed by most tissues. Present in plasma. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7WRQ (EM 3.60A ) |
| DBSNP | rs2854746 rs34257987 rs9282734 rs35712717 rs538312081 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:20353938}. |
| Mouse PG classification | NA |
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