Gene Information
Gene NameIGF2
OrganismHomo sapiens (Human)
Gene Length180
Protein NamesInsulin-like growth factor II (IGF-II) (Somatomedin-A) (T3M-11-derived growth factor) [Cleaved into: Insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; Preptin]
Target Nameinsulin-like growth factor-ii
Target TypeClinical trial target
Gene Age645 ( ENSG00000167244 )
Evolutionary StageEumetazoa
AlphaFoldDBP01344
Gene CardIGF2
Uniprot IDP01344
PfamPF08365; PF00049
In ASDno
Allosteric Predictionyes (0.700425114)
Ortholog in AnimalsAlpaca_ IGF2 ( ortholog_one2one )
Dog_ IGF2 ( ortholog_one2one )
GuineaPig_ IGF2 ( ortholog_one2one )
Macaque_ IGF2 ( ortholog_one2one )
Mouse_ Igf2 ( ortholog_one2one )
Rat_ Igf2 ( ortholog_one2one )
OhnologsNA
ParalogsIGF1, INS
TissueNA
Tissue SpecificityExpressed in heart, placenta, lung, liver, muscle, kidney, tongue, limb, eye and pancreas. {ECO:0000269|PubMed:16531418}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1IGL  (NMR  -  )  2L29  (NMR  -  )  2V5P  (X-ray  4.10A  )  3E4Z  (X-ray  2.28A  )  3KR3  (X-ray  2.20A  )  5L3L  (NMR  -  )  5L3M  (NMR  -  )  5L3N  (NMR  -  )  6UM2  (EM  4.32A  )  6VWG  (EM  3.21A  )  6VWI  (EM  3.70A  ) 
DBSNP rs14367  rs1050342  rs12993 
Subcellular location [CC]Secreted {ECO:0000269|PubMed:16040806}.
Mouse PG classificationLPG
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