| Gene Information | |
|---|---|
| Gene Name | CPNE6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 557 |
| Protein Names | Copine-6 (Copine VI) (Neuronal-copine) (N-copine) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000100884 ) 3 ( ENSG00000285221 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O95741 |
| Gene Card | CPNE6 |
| Uniprot ID | O95741 |
| Pfam | PF00168; PF07002 |
| In ASD | no |
| Allosteric Prediction | yes (0.301004418) |
| Ortholog in Animals | Alpaca_ CPNE6 ( ortholog_one2one ) GuineaPig_ CPNE6 ( ortholog_one2one ) Macaque_ CPNE6 ( ortholog_one2one ) Mouse_ Cpne6 ( ortholog_one2one ) Pig_ CPNE6 ( ortholog_one2one ) Rat_ Cpne6 ( ortholog_one2one ) Rabbit_ CPNE6 ( ortholog_one2one ) |
| Ohnologs | CPNE2, CPNE7, CPNE3, CPNE5 |
| Paralogs | CPNE3, CPNE5, CPNE7, CPNE8, CPNE1, CPNE2, CPNE9, CPNE4 |
| Tissue | brain, cerebral.cortex |
| Tissue Specificity | Widely expressed in the brain (PubMed:9645480, PubMed:10403379, PubMed:12949241). Expressed weakly in the kidney, liver and fetal heart (PubMed:12949241). Expressed in melanocytes (PubMed:23999003). {ECO:0000269|PubMed:10403379, ECO:0000269|PubMed:12949241, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:9645480}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q9Z140}. Cell membrane {ECO:0000250|UniProtKB:Q9Z140}. Endosome {ECO:0000250|UniProtKB:Q9Z140}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q9Z140}. Perikaryon {ECO:0000250|UniProtKB:Q9Z140}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9Z140}. Note=Mainly cytoplasmic in absence of calcium. Associated predominantly with membranes in presence of calcium. Translocates to the cell membrane in a calcium-dependent manner. Colocalized with transferrin in intracellular clathrin-coated membrane vesicles in a calcium-dependent manner. {ECO:0000250|UniProtKB:Q9Z140}. |
| Mouse PG classification | NA |
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