Gene Information
Gene NameIGF1
OrganismHomo sapiens (Human)
Gene Length195
Protein NamesInsulin-like growth factor I (IGF-I) (Mechano growth factor) (MGF) (Somatomedin-C)
Target Nameinsulin-like growth factor-i
Target TypeClinical trial target
Gene Age544 ( ENSG00000017427 )
Evolutionary StageVertebrata
AlphaFoldDBP05019
Gene CardIGF1
Uniprot IDP05019
PfamPF00049
In ASDno
Allosteric Predictionyes (0.873742583)
Ortholog in AnimalsAlpaca_ IGF1 ( ortholog_one2one )
Dog_ IGF1 ( ortholog_one2one )
GuineaPig_ IGF1 ( ortholog_one2one )
Macaque_ IGF1 ( ortholog_one2one )
Mouse_ Igf1 ( ortholog_one2one )
Pig_ IGF1 ( ortholog_one2one )
Rat_ Igf1 ( ortholog_one2one )
Rabbit_ IGF1 ( ortholog_one2one )
OhnologsNA
ParalogsINS, IGF2
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.003717(Rat);0.06(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1B9G  (NMR  -  )  1BQT  (NMR  -  )  1GZR  (X-ray  2.00A  )  1GZY  (X-ray  2.54A  )  1GZZ  (X-ray  2.30A  )  1H02  (X-ray  2.00A  )  1H59  (X-ray  2.10A  )  1IMX  (X-ray  1.82A  )  1PMX  (NMR  -  )  1TGR  (X-ray  1.42A  )  1WQJ  (X-ray  1.60A  )  2DSP  (X-ray  2.50A  )  2DSQ  (X-ray  2.80A  )  2DSR  (X-ray  2.10A  )  2GF1  (NMR  -  )  3GF1  (NMR  -  )  3LRI  (NMR  -  )  4XSS  (X-ray  3.00A  )  5U8Q  (X-ray  3.27A  )  6FF3  (X-ray  2.57A  )  6PYH  (EM  4.30A  )  6RVA  (NMR  -  )  7S0Q  (EM  3.70A  )  7WRQ  (EM  3.60A  ) 
DBSNP rs587779350  rs17884626  rs6213 
Subcellular location [CC]Secreted {ECO:0000250|UniProtKB:P05017}.
Mouse PG classificationLPG
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