| Gene Information | |
|---|---|
| Gene Name | MAPK6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 721 |
| Protein Names | Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK) |
| Target Name | mitogen-activated protein kinases |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000069956 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q16659 |
| Gene Card | MAPK6 |
| Uniprot ID | Q16659 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | no (-0.141588232) |
| Ortholog in Animals | Alpaca_ MAPK6 ( ortholog_one2one ) Dog_ MAPK6 ( ortholog_one2one ) GuineaPig_ MAPK6 ( ortholog_one2one ) Macaque_ MAPK6 ( ortholog_one2one ) Mouse_ Mapk6 ( ortholog_one2one ) Pig_ MAPK6 ( ortholog_one2one ) Rat_ Mapk6 ( ortholog_one2one ) Rabbit_ MAPK6 ( ortholog_one2one ) |
| Ohnologs | MAPK4 |
| Paralogs | MAPK8, MAPK10, MAPK1, MAPK12, MAPK13, SRPK1, SRPK3, MAPK4, NLK, MAPK14, MAPK3, MOK, MAPK11, MAK, MAPK15, MAPK7, SRPK2, MAPK9, CILK1 |
| Tissue | NA |
| Tissue Specificity | Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6YKY (X-ray 2.52A ) 6YLC (X-ray 2.43A ) 6YLL (X-ray 2.89A ) 7AQB (X-ray 2.25A ) |
| DBSNP | rs35697691 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates to the cytoplasm following interaction with MAPKAPK5. {ECO:0000250}. |
| Mouse PG classification | NA |
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