| Gene Information | |
|---|---|
| Gene Name | IFT88 |
| Organism | Homo sapiens (Human) |
| Gene Length | 824 |
| Protein Names | Intraflagellar transport protein 88 homolog (Recessive polycystic kidney disease protein Tg737 homolog) (Tetratricopeptide repeat protein 10) (TPR repeat protein 10) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000032742 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q13099 |
| Gene Card | IFT88 |
| Uniprot ID | Q13099 |
| Pfam | PF13174; PF13181 |
| In ASD | no |
| Allosteric Prediction | no (-1.093619465) |
| Ortholog in Animals | Alpaca_ IFT88 ( ortholog_one2one ) Dog_ IFT88 ( ortholog_one2one ) GuineaPig_ IFT88 ( ortholog_one2one ) Macaque_ IFT88 ( ortholog_one2one ) Mouse_ Ift88 ( ortholog_one2one ) Pig_ IFT88 ( ortholog_one2one ) Rat_ Ift88 ( ortholog_one2one ) Rabbit_ IFT88 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | BBS4, OGT, CFAP70, TTC34, TTC6, TMTC1, TTC16, TMTC4, TTC13, TTC7A, TMTC2, TMTC3, TTC8, TTC7B |
| Tissue | NA |
| Tissue Specificity | Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas. {ECO:0000269|PubMed:7633404}. |
| Pharmacological Animal Models | 0.031255(Chimpanzee);0.043734(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2442455 rs9509307 rs9552254 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q61371}. Cell projection, cilium {ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:28428259}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:27767179, ECO:0000269|PubMed:28428259, ECO:0000269|PubMed:28625565}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:27767179}. Cytoplasm {ECO:0000250|UniProtKB:Q61371}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q61371}. Note=Colocalizes with ENTR1 and gamma-tubulin at the basal body of primary cilia. Colocalizes with ENTR1 and pericentrin at the centrosome. {ECO:0000269|PubMed:27767179}. |
| Mouse PG classification | NA |
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