| Gene Information | |
|---|---|
| Gene Name | IFT74 |
| Organism | Homo sapiens (Human) |
| Gene Length | 600 |
| Protein Names | Intraflagellar transport protein 74 homolog (Capillary morphogenesis gene 1 protein) (CMG-1) (Coiled-coil domain-containing protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000096872 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96LB3 |
| Gene Card | IFT74 |
| Uniprot ID | Q96LB3 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.443141891) |
| Ortholog in Animals | Alpaca_ IFT74 ( ortholog_one2one ) Dog_ IFT74 ( ortholog_one2one ) GuineaPig_ IFT74 ( ortholog_one2one ) Macaque_ IFT74 ( ortholog_one2one ) Mouse_ Ift74 ( ortholog_one2one ) Pig_ IFT74 ( ortholog_one2one ) Rat_ Ift74 ( ortholog_one2one ) Rabbit_ IFT74 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in adult and fetal kidney and expressed at lower level in adult heart, placenta, lung, liver and pancreas, and in fetal heart, lung and liver. Little to no expression was detected in adult brain and skeletal muscle or in fetal brain, thymus and spleen (PubMed:11683410). Detected in sperm (at protein level) (PubMed:33689014). {ECO:0000269|PubMed:11683410, ECO:0000269|PubMed:33689014}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003133(Rat);0.053333(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs751583919 rs10812505 rs11555693 rs12004404 rs150219690 rs17694549 rs1056125920 rs34628525 rs138591335 rs3429 |
| Subcellular location [CC] | Cell projection, cilium {ECO:0000269|PubMed:15024030}. Cytoplasmic vesicle {ECO:0000269|PubMed:11683410}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:33689014}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q8BKE9}. Note=Localizes along primary cilia at interphase and around the basal body/centriole at interphase and mitosis (PubMed:15024030). In male germ cells, strongly expressed in the vesicles of spermatocytes and round spermatids and also in the acrosome and centrosome regions of elongating spermatids and in developing sperm tails (By similarity). {ECO:0000250|UniProtKB:Q8BKE9, ECO:0000269|PubMed:15024030}. |
| Mouse PG classification | NA |
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