| Gene Information | |
|---|---|
| Gene Name | IFT144 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1342 |
| Protein Names | WD repeat-containing protein 19 (Intraflagellar transport 144 homolog) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8NEZ3 |
| Gene Card | WDR19 |
| Uniprot ID | Q8NEZ3 |
| Pfam | PF15911 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Some isoforms are tissue-specific. Highly expressed in the prostate. Lower expression in the cerebellum, pituitary gland, fetal lung, and pancreas. In normal prostate, expressed in both basal and luminal epithelial cells. No expression detected in fibromuscular stromal cells, endothelial cells, or infiltrating lymphocytes. Uniformed expression in prostate adenocarcinoma cells. {ECO:0000269|PubMed:12906858}. |
| Pharmacological Animal Models | 0.122000(Chimpanzee);0.148785(Mouse);0.002990(Rat);0.040000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs387906982 rs776967770 rs786204852 rs766029437 rs199812132 rs387906983 rs587777349 rs387906980 rs16995209 rs79436363 rs587777351 |
| Subcellular location [CC] | Cell projection, cilium {ECO:0000250|UniProtKB:Q3UGF1}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q3UGF1}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q3UGF1}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:32323121}. Note=Localizes to photoreceptor connecting cilia, to the base of motile cilia in brain ependymal cells and to the base of and along primary cilia in kidney cells. Localizes at the sperm neck and flagellum (PubMed:32323121). {ECO:0000250|UniProtKB:Q3UGF1, ECO:0000269|PubMed:32323121}. |
| Mouse PG classification | NA |
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