| Gene Information | |
|---|---|
| Gene Name | BMP4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 408 |
| Protein Names | Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B) |
| Target Name | bone morphogenetic protein 4 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000125378 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P12644 |
| Gene Card | BMP4 |
| Uniprot ID | P12644 |
| Pfam | PF00019; PF00688 |
| In ASD | no |
| Allosteric Prediction | yes (0.034167644) |
| Ortholog in Animals | Alpaca_ BMP4 ( ortholog_one2many ) Dog_ BMP4 ( ortholog_one2one ) GuineaPig_ BMP4 ( ortholog_one2one ) Macaque_ BMP4 ( ortholog_one2one ) Mouse_ Bmp4 ( ortholog_one2one ) Pig_ BMP4 ( ortholog_one2one ) Rat_ Bmp4 ( ortholog_one2one ) Rabbit_ BMP4 ( ortholog_one2one ) |
| Ohnologs | BMP2, GDF5, BMP5, GDF7, BMP10 |
| Paralogs | BMP3, MSTN, INHBC, GDF15, BMP6, INHBA, GDF6, TGFB3, BMP2, BMP10, TGFB1, INHA, GDF9, GDF11, BMP5, BMP7, INHBB, GDF5, GDF1, GDF2, LEFTY1, LEFTY2, GDF3, INHBE, GDF7, GDF10, BMP15, TGFB2, BMP8A, BMP8B, NODAL |
| Tissue | NA |
| Tissue Specificity | Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines. |
| Pharmacological Animal Models | 0.012047(Chimpanzee);0.186334(Mouse);0.001578(Rat);0.055556(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs121912767 rs121912765 rs202159001 rs750427266 rs767216159 rs17563 rs770493925 rs144556455 rs140590144 rs121912768 rs121912766 rs1320581580 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix. |
| Mouse PG classification | HPG |
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