| Gene Information | |
|---|---|
| Gene Name | IFNGR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 337 |
| Protein Names | Interferon gamma receptor 2 (IFN-gamma receptor 2) (IFN-gamma-R2) (Interferon gamma receptor accessory factor 1) (AF-1) (Interferon gamma receptor beta-chain) (IFN-gamma-R-beta) (Interferon gamma transducer 1) |
| Target Name | interferon gamma receptor 2 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000159128 ) 3 ( ENSG00000262795 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P38484 |
| Gene Card | IFNGR2 |
| Uniprot ID | P38484 |
| Pfam | PF09294; PF01108 |
| In ASD | no |
| Allosteric Prediction | yes (0.279839636) |
| Ortholog in Animals | Alpaca_ IFNGR2 ( ortholog_one2one ) Alpaca_ IFNGR2 ( ortholog_one2many ) Dog_ IFNGR2 ( ortholog_one2one ) GuineaPig_ IFNGR2 ( ortholog_one2one ) Macaque_ IFNGR2 ( ortholog_one2one ) Mouse_ Ifngr2 ( ortholog_one2one ) Pig_ IFNGR2 ( ortholog_one2one ) Rat_ Ifngr2 ( ortholog_one2one ) Rabbit_ IFNGR2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IFNAR1, IL22RA2, IL22RA1, F3, IFNLR1, IL10RA, IL20RB, IL20RA, IFNAR2, IFNGR1, IL10RB |
| Tissue | NA |
| Tissue Specificity | Expressed in T-cells (at protein level). {ECO:0000269|PubMed:10605012}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.035650(Mouse);0.007657(Rat);0.050000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5EH1 (X-ray 1.80A ) 6E3K (X-ray 3.25A ) 6E3L (X-ray 3.80A ) |
| DBSNP | rs4986958 rs9808753 rs1243506079 rs1196094724 rs17878639 rs74315444 rs17878711 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15356148, ECO:0000269|PubMed:15924140, ECO:0000269|PubMed:27599734}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10605012}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:23963039}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23963039}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:10605012}. Note=Has low cell surface expression and high cytoplasmic expression in T cells. The bias towards cytoplasmic expression may be due to ligand-independent receptor internalization and recycling. {ECO:0000269|PubMed:10605012, ECO:0000269|PubMed:15356148}. |
| Mouse PG classification | HPG |
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