| Gene Information | |
|---|---|
| Gene Name | NAV3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2385 |
| Protein Names | Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000067798 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8IVL0 |
| Gene Card | NAV3 |
| Uniprot ID | Q8IVL0 |
| Pfam | PF00004; PF00307 |
| In ASD | no |
| Allosteric Prediction | no (-0.952121785) |
| Ortholog in Animals | Alpaca_ NAV3 ( ortholog_one2one ) Dog_ NAV3 ( ortholog_one2one ) GuineaPig_ NAV3 ( ortholog_one2one ) Macaque_ NAV3 ( ortholog_one2one ) Mouse_ Nav3 ( ortholog_one2one ) Pig_ NAV3 ( ortholog_one2one ) Rat_ Nav3 ( ortholog_one2one ) Rabbit_ NAV3 ( ortholog_one2one ) |
| Ohnologs | NAV1, NAV2 |
| Paralogs | NAV1, NAV2 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in brain. Expressed at low levels in heart and placenta. Present in activated T-cells but not in resting T-cells (at protein level). Down-regulated in primary neuroblastoma. {ECO:0000269|PubMed:12062803, ECO:0000269|PubMed:12079279, ECO:0000269|PubMed:15158073, ECO:0000269|PubMed:16166283}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.117317(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs10735309 rs34195711 |
| Subcellular location [CC] | Nucleus outer membrane {ECO:0000250|UniProtKB:Q80TN7}. |
| Mouse PG classification | NA |
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