| Gene Information | |
|---|---|
| Gene Name | XRN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1706 |
| Protein Names | 5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000114127 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8IZH2 |
| Gene Card | XRN1 |
| Uniprot ID | Q8IZH2 |
| Pfam | PF18129; PF18332; PF18334; PF17846; PF03159 |
| In ASD | no |
| Allosteric Prediction | no (-0.682505558) |
| Ortholog in Animals | Alpaca_ XRN1 ( ortholog_one2one ) Dog_ XRN1 ( ortholog_one2one ) Macaque_ XRN1 ( ortholog_one2one ) Mouse_ Xrn1 ( ortholog_one2one ) Pig_ XRN1 ( ortholog_one2one ) Rat_ Xrn1 ( ortholog_one2one ) Rabbit_ XRN1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | XRN2 |
| Tissue | NA |
| Tissue Specificity | Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines. {ECO:0000269|PubMed:12426100}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001962(Rat);0.025641(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35214510 rs35902661 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12515382, ECO:0000269|PubMed:14580940, ECO:0000269|PubMed:9802570}. Note=Discrete foci at the inner surface of the cell membrane. |
| Mouse PG classification | NA |
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